Drug Allergies

What causes my drug allergies?

If you have side effects that concern you, or you suspect a drug allergy has occurred, call us to help investigate. The majority of reactions to medication or vaccines are not true allergies. At Auni Allergy we help focus on one medication at a time, reviewing your reaction history and outside records you provide. 

An allergic reaction occurs when the immune system overreacts to a harmless substance, in this case a medication, which triggers an allergic reaction. Sensitivities or side effects to drugs may produce similar symptoms, but are not IgE-mediated. IgE-mediated or true allergic reactions can be life-threatening. It is important to know if your reactions are due to an IgE-mediated allergy..

How do we evaluate your drug allergies?

Drug allergy can be complicated, especially when more than one drug is in question. We focus on one drug at a time, gathering a detailed history about your reaction. If indicated based on your reaction history, allergy skin testing can help identify IgE-mediated allergy. 

If skin testing to the drug is negative or not recommended, a drug challenge is the next step in ruling out life-threatening allergy. Drug challenge involves taking a very small amount of the drug in question in our office. If tolerated, the rest of a dose will be administered under close observation.

Auni Allergy Treatment Experiences

De-Labeling Drug Allergy

It is important to sort out life-threatening allergy from side effect in order to prevent avoiding first-line treatments un-necessarily. De-labeling drug allergy is the process of taking a medication in a controlled medical setting to confirm that you can tolerate it. This is the gold standard for ruling out drug allergy and allows you to remove that medication from your drug allergy list. De-labeling penicillin allergy helps prevent risks that come along with using stronger antibiotics than necessary and also saves you money.


For those with true IgE-mediated penicillin allergy, desensitization is a procedure that can allow temporary use of penicillin to treat a severe infection. This involves gradually introducing the medication in small doses until the therapeutic dose is achieved. This procedure is performed in a hospital setting.

10% of the population reports a penicillin allergy but <1% of the whole population is truly allergic. De-labeling drug allergy is an important part of protecting your health for the future.

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